Supercritical Fluid Chromatography (SFC) systems, such as the SFC 30, SFC 50, and SFC 100 from SFC Process, offer several standout features that optimize the extraction and purification processes:
1. High Extraction Efficiency
- Utilizes supercritical CO₂ to enhance the solubility of compounds compared to HPLC.
- Delivers higher extraction efficiency with improved chromatographic resolution, especially for non-polar or chiral (optical isomer) compounds.
- Enables faster purification and separation while maintaining high quality.
2. CO₂ Recycling for Cost Savings
- The system can recover and reuse CO₂, reducing waste and lowering operating costs.
- A low CO₂ loss rate (~10%) minimizes environmental impact compared to traditional purification methods.
3. Co-solvent Support for Polarity Adjustment
- Can incorporate co-solvents (methanol, ethanol, acetonitrile) to expand the solubility range of CO₂, facilitating the purification of a variety of compounds.
- Allows for the adjustment of co-solvent ratios to optimize extraction performance.
4. Flexible and Customizable Design
- Available with various chromatographic column sizes (30 mm, 50 mm, 100 mm) to meet demands ranging from preparative scale to industrial production.
- The system can be scaled and customized according to customer requirements, fitting different manufacturing processes.
- Compact design saves space and is easy to install and integrate into production lines.
5. User-Friendly Control Interface
- Equipped with intuitive control software that allows operators to easily monitor and adjust chromatographic parameters.
- Integrated remote monitoring capabilities enable process control without direct intervention.
6. Continuous Operation for Optimized Performance
- Allows for the replacement of CO₂ containers without interrupting operation, enhancing production efficiency.
- Capable of 24/7 operation with high stability.
SFC Process offers three models of supercritical CO₂ purification systems—SFC 30, SFC 50, and SFC 100. The main differences among these models lie in the column size, CO₂ flow rate, and co-solvent flow rate, making them suitable for various applications ranging from preparative to industrial-scale production.
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