SUPERCRITICAL CO2 PURIFICATION SYSTEM – SFC Process

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The SFC (Supercritical Fluid Chromatography) system is used for the extraction and purification of compounds. It utilizes supercritical CO₂ to efficiently separate compounds, especially hydrophobic and chiral (optical isomer) compounds. This system is suitable for pharmaceuticals, food, cosmetics, chemicals, and many other industries.

Supercritical Fluid Chromatography (SFC) systems, such as the SFC 30, SFC 50, and SFC 100 from SFC Process, offer several standout features that optimize the extraction and purification processes:

1. High Extraction Efficiency

  • Utilizes supercritical CO₂ to enhance the solubility of compounds compared to HPLC.
  • Delivers higher extraction efficiency with improved chromatographic resolution, especially for non-polar or chiral (optical isomer) compounds.
  • Enables faster purification and separation while maintaining high quality.

2. CO₂ Recycling for Cost Savings

  • The system can recover and reuse CO₂, reducing waste and lowering operating costs.
  • A low CO₂ loss rate (~10%) minimizes environmental impact compared to traditional purification methods.

3. Co-solvent Support for Polarity Adjustment

  • Can incorporate co-solvents (methanol, ethanol, acetonitrile) to expand the solubility range of CO₂, facilitating the purification of a variety of compounds.
  • Allows for the adjustment of co-solvent ratios to optimize extraction performance.

4. Flexible and Customizable Design

  • Available with various chromatographic column sizes (30 mm, 50 mm, 100 mm) to meet demands ranging from preparative scale to industrial production.
  • The system can be scaled and customized according to customer requirements, fitting different manufacturing processes.
  • Compact design saves space and is easy to install and integrate into production lines.

5. User-Friendly Control Interface

  • Equipped with intuitive control software that allows operators to easily monitor and adjust chromatographic parameters.
  • Integrated remote monitoring capabilities enable process control without direct intervention.

6. Continuous Operation for Optimized Performance

  • Allows for the replacement of CO₂ containers without interrupting operation, enhancing production efficiency.
  • Capable of 24/7 operation with high stability.

SFC Process offers three models of supercritical CO₂ purification systems—SFC 30, SFC 50, and SFC 100. The main differences among these models lie in the column size, CO₂ flow rate, and co-solvent flow rate, making them suitable for various applications ranging from preparative to industrial-scale production.

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