Simplified Access, Cleaning and Changeover
Pharma 24 features a hinged, split-barrel configuration that provides convenient access to product-contact areas for routine cleaning, inspection, and process configuration changes. The barrel can be disassembled without requiring specialized handling equipment, helping simplify maintenance and reduce downtime.
All product-contact components are designed for easy removal, allowing thorough external cleaning and visual inspection to support “visibly clean” requirements.
Quick-connect fittings for utilities and power further streamline equipment setup and disassembly, making post-production cleaning and preparation more efficient.
Flexible Process Configuration
The fully ported split barrel incorporates eight independently controlled heating and cooling zones, providing precise thermal management throughout the extrusion process. With an operating pressure of up to 100 bar, the system offers broad process flexibility for a wide range of pharmaceutical formulations and manufacturing requirements.
Removable barrel liners provide additional convenience during product changeovers. By preparing a second set of product-contact components in advance, manufacturers can significantly reduce overall changeover time, improving equipment availability and production efficiency.
Designed for GMP-Oriented Manufacturing
Every aspect of the Pharma 24 is engineered with reliable operation, ease of handling, and effective cleaning in mind. Its compact, crevice-minimized housing helps support hygienic operation and GMP-oriented manufacturing environments.
The product-contact components can be readily disassembled for cleaning and inspection, helping minimize product residue and supporting consistent manufacturing standards.
Intelligent Control and System Integration
Pharma 24 is equipped with comprehensive, industry-standard control and operating software designed for straightforward operation and integration with surrounding process equipment.
The system supports plug-and-play connectivity with upstream and downstream equipment, enabling efficient integration into continuous or automated manufacturing lines.
Key software capabilities include:
• User management and access control
• Recipe management
• Audit trail functionality
• Integration with upstream and downstream process equipment
A Complete Solution for HME and TSG Applications
Combining compact design, flexible process control, efficient cleaning, simplified changeover, and integrated system management, the Thermo Scientific™ Pharma 24 Twin-screw Extruder provides a practical solution for pharmaceutical manufacturers moving toward reliable and scalable commercial production.
Designed with both process performance and operational efficiency in mind, Pharma 24 helps manufacturers streamline production workflows while maintaining the control and flexibility required for modern HME and TSG applications.
Main Benefits
- Compact, space-saving design
- Easy to clean
- Easy to disassemble and assemble without additional tools
- No separate control cabinet required; electronic components are integrated into the extruder base
- Integrated control software for upstream and downstream process equipment
- Compliant with 21 CFR Part 11
- Audit Trail and batch reporting functions
High-Throughput Applications
Complete Configurations for HME & TSG
The Pharma 24 Twin-screw Extruder is designed to support high-throughput Hot Melt Extrusion (HME) and Twin-screw Granulation (TSG) applications with dedicated, application-specific configurations. Each setup includes pre-configured screw shafts and the required screw elements to ensure efficient and consistent processing.
For HME applications, the complete setup includes a die heater, die adapter, temperature control system, and an integrated melt temperature and pressure sensor for precise process monitoring.
The TSG configuration features a discharge chute equipped with a good/waste material diverter valve and dedicated collection bins, enabling efficient separation and collection of processed materials.
Compact Production, Maximum Efficiency
For high-throughput HME manufacturing, the optional chill roll provides an efficient solution for downstream processing. Despite its comprehensive configuration, the complete production setup—including the extruder and chill roll—can be installed within less than 3 m² of laboratory space.
Expertise That Accelerates Your Production
With outstanding flexibility and the support of an experienced international applications team, the Pharma 24 Twin-screw Extruder can serve as the core of a complete manufacturing solution. From process development to production optimization, our expertise helps improve overall productivity, streamline workflows, and accelerate your time to market.
Technical data
| Parameter | Specification |
|---|---|
| Screw Length | HME L/D = 40 (40 × 24 mm = 960 mm)TSG L/D = 40.75 (40.75 × 24 mm = 978 mm) |
| Barrel Zoning | 7 barrel zones: Zone 2–8 (electrical heating, cooling by solenoid valves)Optionally 1–3 heated die zones |
| Temperature | 10–300 °C |
| Maximum Pressure | 100 bar |
| Screw Speed | 10–1,000 rpm |
| Throughput | HME: 2–20 kg/h; TSG: 4–60 kg/h (rate depends on formulation) |
| Torque | 105 Nm (52.5 Nm/shaft) |
| Main Supply | 3 × 400 V / N / PE, 50/60 Hz @ 63 A |
| Dimensions (L × W × H) | 2,100 × 850 × 1,730 mm |
| Centerline Height | 1,050 mm |
| Footprint with Chill Roll | L × W × H approx. 3,200 × 850 × 1,730 mm |
| Weight | 560 kg |
